Literature

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Noto, V., Taper, H., Yi_Hua, J., Janssens, J., Bonte, J., and DeLoecker, W., Effects of Sodium Ascorbate (Vitamin C) and 2-Methyl-1,4-Napthoquinone (Vitamin K3) Treatment on Human Tumor Cell Growth in Vitro I. Synergism of Combined Vitamin C and K3 Action, Cancer, 1989, 63, pg. 901 – 906.

Taper, H., and Roberfroid, M., Non-Toxic Sensitization of Cancer Chemotherapy by Combined Vitamin C and K3 Pretreatment in a Mouse Tumor resistant to Oncovin, Anticancer Research, 1992, 12, pg. 1651 – 1654.

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Gilloteaux, J., Jamison, J., Venugopal, M., Giammar, D., and Summers, J.L., Scanning electron microscopy and transmission electron microscopy aspects of synergistic antitumor activity of Vitamin C – Vitamin K3 Combination against human prostatic cancinoma cells, Scanning Microscopy, 1995, 9(1), pg. 159-173.

Venugopal, M., Jamison, J., Gilloteaux,J., Koch, J., Summers, M., Hoke,J., Sowick, C., and. Summers,J.L.,Synergistic antitumour activity of vitamins c and k3 against human prostate carcinoma cell lines, Cell Biology International, 1996, 20(12) pg. 787 – 797.

Venugopal,M., Jamison,J., Gilloteaux,J., , Koch, J., Summers,M., Hoke,J., Giammar, D. Sowick, C., and. Summers, J.L.,Synergistic antitumour activity of vitamins C and K3 against human urologic tumors, Life Sciences, 1996, 59(17)pg. 1389 – 1400

Jamison, J., Gilloteaux, J., Venugopal, M., Koch, J., Sowick, C., Shah, R., and Summers, J.L., Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of Vitamin C –vitamin K3 conbinations against human prostatic carcinoma cells, Tissue and Cell, 1996, 28(6), pg. 687 – 701.

Taper, H., Keyeux, A., and Roberfroid, M., Potentiation of Radiotherapy by Nontoxic Pretreatment with Combined Vitamin C and K3 in Mice Bearing Solid Transplantable Tumor,Anticancer research, 1996, 16,pg. 499 – 504.

Gilloteaux,J., Jamison,JArnold, D., Ervin, E., Eckroat, L., Docherty, J., Neal DR and Summers ,JL, Cancer Cell Neucrosis by Autoschizis: Synrgism of Antitumor Activity of Vitamin C: Vitamin K3 on Human Bladder Carcinoma T24 Cells, Scanning, 1998,20, pg. 564 – 575.

Jamison, J., Gilloteaux, J., Neal, D., and Summers, J.L., Characterization of the Early Events in Vitamin C and K3-Induced Death of Human Prostate Tumor Cells, Proceedings of Scanning, 1999, pg. 107 – 108.

Nassiri, M., Gilloteaux, J., Jamison, J., and Summers, J.L., Flow Cytometric Evaluation of Two Human Carcinoma Cell Lines Confirms Cell Autoschizis Potentiated by the Synergism of Vitamin C and K3, Scanning, 1999, 21 (2), pg. 108.

Arnold, D., Gilloteaux, J., Jamison, J., and Summers, J.L., Synergistic Effects of Vitamin C: Vitamin K3 o Human Renal Adenocarcinoma Cell Line (Caki-1): Scanning Electron Microscopy, Proceedings of Scanning, 1999, pg. 109 -110.

Gilloteaux, J., Jamison, J., Arnold, D., VonGreunigen, V., Hower, R., Taper, H., and Summers, J.L., Cell Death by Autoschizis for Bladder (T24) and Ovarian Carcinoma (MDAH) Cells: LM and SEM Aspects of Morphologic Changes Induced by the Synergistic Antitumor Activity of Vitamin C:Vitamin K3 Combinations, Proceedings of Scanning, 2000, pg. 119.

Gilloteaux, J., Jamison, J., Arnold, D., and Summers, J.L.,Autoschizis; A new form of cell death, It. J. of Anatomy and Embryology, 2001, 106, pg 79-82.

Taper, H., Jamison, J., Gilloteaux, J., Grin, C., Gordon, T., and Summers, J.L., In Vivo Reactivation of DNases in Implanted Human Proste Tumors after Administration of Vitamin C/K3 Combination, The J. of Histochem. And Cytochem., 2001, 49(1),pg. 109 – 119.

Jamison, J., Gilloteaux, J., Taper, H., and Summers, J.L., Evaluation of the In Vitro and In Vivo Antitumor Activities of Vitamin C and K3 Combinations against Human Proste Cancer, J. of Nutrition, 2001, 131, pg. 1588 – 1605.

Gilloteaux, J., Jamison, J., Arnold, D., Taper, H., and Summers, J.L., Ultrastructural Aspects of Autoschizis: A Novel Cancer Cell Death by the Synergistic Action of Ascorbate/Menadione on Human Bladder Cancinoma Cells, Ultrastructural Pathology, 2001, 25, pg. 183 – 191.

Jamison, J., Gilloteaux, Taper, H., Buc Calderon, B., and Summers, J.L., Autoschizis: A novel cell death, Biochem. Pharma., 2002, 63, pg. 1773 – 1783.

Buc Calderon, P., Cadrobbi, J., Marques, C., Hong-Ngoc, N., Jamison, J., Gilloteaux, J., Summers, J.L., and Taper, H., Potential Therapeutic Application of the Association of Vitamin C and K3 in Cancer Treatment, Current Medicinal Chemistry, 2002, 9, pg. 2269 – 2285.

Lasalvia-Prisco, E., Cucchi, S., Vazquez,J., Lasalvia-Galante, E., Golomar, W., and Gordon, W., Serum Markers Variation Consistent with Autoschizis Induced by Ascorbic Acid-Menadione in Patients with Prostate Cancer, Medical Oncology, 2003, 20(1), pg. 1-8.

Von Gruenigen, V., Jamison, J., Gilloteaux, J., Lorimer, H., Pollard, R., Gwin, C., and Summers, J.L., The In Vitro Antitumor Activity of Vitamins C and K3 against Ovarian Carcinoma, Anticancer Research, 2003, 23, pg. 3279 – 3288.

Verrax J, Cadrobbi J, Delvaux M, Jamison JM, Gilloteaux J, Summers JL, Taper HS and Buc Calderon P. The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death.Basis for their potential use as coadjuvants in anticancer therapy. Eur J Med Chem 2003; 38: 451-457.

Gilloteaux, J., Jamison, J., Arnold, D., Taper, H., von Gruenigen, V. and Summers, J.L., Microscopic Aspects of Autoschizic Cell Death in Human Ovarian Carcinoma (2774) Cells Following Vitamin C, Vitamin K3, or Vitamin C: K3 Treatment, Microscopy and Microanalysis, 2003, 9, pg. 311 – 329.

Gilloteaux, J., Jamison, J., Jarjoura, D., Von Gruenigen, V., and Summers, J.L., Autoschizis of Human Ovarian Carcinoma Cells: Scanning Electron and light Microscopy of a New Cell Death Induced by Sodium Ascorbate: Menadione Treatment, Scanning, 2003, 23, pg. 137 – 149.

Taper, H., Jamison, J., Gilloteaux, J., Summers, J.L., and Buc Calderon, P., Inhibition of the development of metastates by dietary vitamin C:K3 combination, Life Sciences, 2004, 75, pg. 955 – 967.

Gilloteaux,J., Jamison,J., Lorimer, H., Jarjoura, D., Taper, H., Calderon, P., Neal DR and Summers ,JL, Autoschizis: a new form of cell death for human ovarian carcinoma cells following ascorbate: medadione treatment, Tissue and Cell, 2004; 36: 197- 209.

Jamison JM, Gilloteaux J, Nassiri MR, Venugopal M , Neal DR and Summers ,JL, Induction of Cell Cycle Arrest and Autoschizis in a Human Bladder Carcinoma Cell Line by Vitamins C and K3. Biochem Pharm, 2004, 67, pg. 337-351.

Verrax,J, Cadrobbi J, Jamison JM, Marques,C, Taper HS, Habraken,Y, Piette,J, Buc Calderon P, Ascorbate potentiates the cytotoxicity of medadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death, Apoptosis, 2004;9, pg. 223 – 233.

Gilloteaux J, Jamison JM, Arnold D, Jarjoura D, Von Greuningen V and Summers JL. Autoschizis of Human Ovarian Carcinoma Cells: SEM and LM of a New Cell Death Induced by Sodium Ascorbate : Menadione Treatment. Tissue & Cell, 2004, 36, pg. 197 – 210.

Jamison JM, Gilloteaux J, Taper HS, Calderon PB, Neal DR, Blank JL, Clemens RJ and Summers JL The In Vitro and In Vivo Antitumor Activity of Vitamin C : K3 Combinations against Prostate Cancer, Progress In Prostate Cancer Research, Columbus, F (ed.), Nova Science Publishers, Inc., Hauppauge, NY. 2005.

Jamison, J, Gilloteaux, J, Tsai, CC, Taper, H, Puc Calderon, P, Perlaky, L, Neal, DR, Blank, J, Getch, S, Summers, JL, Book Chapter Antioxidants: Are they Real? Aug, 2005 Gilloteaux J, Jamison JM, Neal DR, Summers JL Cell death by autoschizis in TRAMP prostate carcinoma cells as a result of treatment by ascorbate: Menadione combination. Ultrastruct Pathol. 2005 May-Aug 29(3-4):221-35. Gilloteaux Jacques; Jamison James M; Arnold David; Neal Deborah R; Summers Jack L
Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment. The Anatomical Record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2006;288A(1):58-83.

Kassouf, W., Highshaw, R., Nelkin, G., Dinney, C., and Kamatt, A., Vitamins C and K3 Sensitize Human Urothelial Tumors to Gemcitabine,The Journal of urology, 2006, 176, pg. 1642 – 1647.

Verrax, J., Vanbever, S., Stocks, J., Taper, H., and Buc Calderson, P., Role of glycolysis inhibition and Poly(ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione induced oxidative stress in K562 human chronic myelogenous leukemia cells, Int J. of Cancer, 2006.

Tareen, Basir, Summers, Jack L., Jamison, James M. J, Neal, Deborah R., McGuire, Karen,Gerson, Lowell ,Diokno, Ananias, A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy, Int J Med Sci , 2008, Mar 24,5(2), pg.62-67.

Kovacik, M, Mostardi, R, Neal, D, Bear, T, Askew, M, Differences in the surface composition of seemingly similar F75 cobalt-chromium micron-sized particulates can Affect synovial fibroblast viability, Colloids and Surfaces B: Biointerfaces, 2008, 65, pg. 269 – 275.

McGuire, K., Jamison, J., Neal, D., Gilloteaux, J., and Summers, J.L., Elucidating the Pathway of Apatone® Induced DNase II Reactivation During Autoschizic Cell Death, Proceedings of Microscopy and Microanalysis, 2009, pg 888 – 889.

Neal, D., McGuire, K., Shah,P., Kovacik, M., Mostardi, R., Walker, J., Ramsier, R., and Jamison, J., Apatone® Treatment Inhibits the Inflammatory Response in Human Synovial Fibroblasts Following Metal Particulate Exposure by Reducing NF-κB Levels, Proceedings of Microscopy and Microanalysis, 2009, pg 894.

Gilloteaux, J, Jamison, J, Neal, D, Loukas,M, Doberzstyn,T, Summers, J, Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione., Ultrastructure Pathology, 2010, 34, 140 – 160.

Jamison,, J, Gillliteaux, J, Perlaky, L, Thiry, M, Smetana, K, Neal, D, McGuire, K, and Summers, J, Nucleolar Changes and Fibrillarin Redistribution Following Apatone Treatment of Human Bladder Carcinoma Cells,Journal of Histochemistry & Cytochemistry, Jul 2010, 58(7), pg. 635 – 651.

Beck, R., Pedrosa, R., Dejeans, N., Glorieux, C., Leveque, P., Gallaz, B., Taper, H., et. Al., Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of oncogenic protein Bcr-Abl. An in vito and in vivo mechanistic study, Invest. New Drugs, 2011, 29(5), pg. 891 – 900.

Gilloteaux, J, Jamison, J., Meal, D., Summers, J.L., and Taper, H., Xenotransplanted Human Prostate Carcinoma (DU145) Cells Develop into Carcinomas and Cribriform Carcinomas: Ultrastructural Aspects, Ultrastructural Pathology,Oct 2012, 36(5), pg. 294–311.

McGuire, K., Jamison, J., Gilloteaux J., Summers, J. Synergistic Antitumor Activity of Vitamins C and K3 on Human Bladder Cancer Cell Lines Journal of Cancer Therapy, 2013, 4, 7-19 doi:10.4236/jct.2013.46A3002 Published Online February 2013 (http://www.scirp.org/journal/jct)

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